How to calculate the correlation coefficient and fitting slop in each column in two matrix?

It would help if you provided more details in your question.  You may want to approach this using a stats operation.  For details execute:

DisplayHelpTopic "StatsLinearRegression"

You can get a typical correlation coefficient for two arrays using StatsCorrelation.  For more information execute:

DisplayHelpTopic "StatsCorrelation"

You can also use the standard curve fitting to fit a line to your data (Analysis Menu->Quick Fit->Line) and then check the V_Rab and V_r2.